/* simplepeptidereview.com — "ledger" visual system (original build)
   Inverted type pairing (sans body / serif display), ink hero band,
   hairline ledger rows instead of cards, left-hand numbered contents rail. */

:root{
  --ink:#0f1a1d;
  --ink-2:#3a4a4e;
  --ink-3:#71838a;
  --rule:#dde5e4;
  --rule-2:#c6d2d0;
  --bg:#f2f5f4;
  --surface:#ffffff;
  --pine:#0d5a51;
  --pine-2:#083f39;
  --rust:#b3653a;
  --gold:#d9b25e;
  --wash:#eaf0ef;
  --shadow:0 1px 0 rgba(15,26,29,.05), 0 8px 24px -18px rgba(15,26,29,.35);
  --mono:"SFMono-Regular",Menlo,Consolas,"Liberation Mono",monospace;
}

*{box-sizing:border-box;margin:0;padding:0}
html{-webkit-text-size-adjust:100%;scroll-behavior:smooth}
body{
  font:16px/1.74 -apple-system,"Segoe UI",Inter,Roboto,system-ui,"Helvetica Neue",Arial,sans-serif;
  color:var(--ink);background:var(--bg);
  -webkit-font-smoothing:antialiased;
}
img,svg{max-width:100%}
h1,h2,h3,h4{font-family:Georgia,"Iowan Old Style","Times New Roman",serif;font-weight:600;letter-spacing:-.01em}
a{color:var(--pine);text-decoration:none;border-bottom:1px solid rgba(13,90,81,.28)}
a:hover{color:var(--pine-2);border-bottom-color:var(--pine-2)}
.wrap{max-width:1180px;margin:0 auto;padding:0 24px}
.mono{font-family:var(--mono);font-size:.74rem;letter-spacing:.09em;text-transform:uppercase}

/* ---------- utility strip ---------- */
.utility{background:var(--ink);color:#9fb2b4}
.utility .wrap{display:flex;justify-content:space-between;gap:14px;padding:6px 24px;flex-wrap:wrap}
.utility span{font-family:var(--mono);font-size:.68rem;letter-spacing:.11em;text-transform:uppercase}
.utility b{color:#e9d9a8;font-weight:600}

/* ---------- header ---------- */
.bar{background:rgba(255,255,255,.96);border-bottom:1px solid var(--rule);position:sticky;top:0;z-index:70;backdrop-filter:blur(7px)}
.bar .wrap{display:flex;align-items:center;gap:26px;padding:13px 24px;flex-wrap:wrap}
.wordmark{display:flex;align-items:center;gap:12px;border:none}
.dotmark{width:34px;height:34px;position:relative;flex:0 0 auto}
.dotmark::before,.dotmark::after{content:"";position:absolute;inset:0;border-radius:50%;border:1.4px solid var(--pine)}
.dotmark::after{inset:7px;border-color:var(--rust);border-style:dashed}
.dotmark i{position:absolute;left:50%;top:50%;width:7px;height:7px;margin:-3.5px 0 0 -3.5px;border-radius:50%;background:var(--ink)}
.wordmark u{display:block;text-decoration:none;font-family:Georgia,serif;font-size:1.06rem;color:var(--ink);letter-spacing:-.01em}
.wordmark u em{display:block;font-family:var(--mono);font-style:normal;font-size:.62rem;letter-spacing:.14em;text-transform:uppercase;color:var(--ink-3);margin-top:4px}
.menu{display:flex;gap:20px;margin-left:auto;flex-wrap:wrap;align-items:center}
.menu a{font-size:.85rem;font-weight:600;color:var(--ink-2);border:none;padding:4px 0;border-bottom:2px solid transparent}
.menu a:hover{color:var(--pine);border-bottom-color:var(--rule-2)}
.menu a[aria-current]{color:var(--ink);border-bottom-color:var(--rust)}
.hamb{display:none;margin-left:auto;width:38px;height:34px;background:none;border:1px solid var(--rule-2);border-radius:2px;color:var(--ink);font-size:1rem;cursor:pointer}

/* ---------- ink hero ---------- */
.hero{background:
   radial-gradient(120% 130% at 88% -18%, rgba(217,178,94,.20) 0%, transparent 58%),
   linear-gradient(180deg,#0f1a1d 0%,#132427 100%);
  color:#e8eef0;position:relative;overflow:hidden;border-bottom:1px solid #05100f}
.hero::after{content:"";position:absolute;inset:0;pointer-events:none;opacity:.30;
  background-image:linear-gradient(rgba(255,255,255,.07) 1px,transparent 1px),
                   linear-gradient(90deg,rgba(255,255,255,.07) 1px,transparent 1px);
  background-size:44px 44px}
.hero .wrap{position:relative;z-index:2;display:grid;grid-template-columns:minmax(0,1.5fr) minmax(0,.8fr);gap:52px;padding:52px 24px 56px;align-items:start}
.hero .eyebrow{font-family:var(--mono);font-size:.68rem;letter-spacing:.16em;text-transform:uppercase;color:#c8a86a;margin-bottom:16px}
.hero h1{font-size:2.32rem;line-height:1.2;color:#fbfdfd;letter-spacing:-.015em}
.hero .intro{margin-top:16px;font-size:1.04rem;color:#b6c5c7;max-width:40em}
.hero .stamp{margin-top:22px;display:flex;gap:18px;flex-wrap:wrap;font-family:var(--mono);font-size:.66rem;letter-spacing:.1em;text-transform:uppercase;color:#8fa3a5}
.hero .stamp b{color:#e9d9a8;font-weight:600}
.ledger{background:rgba(255,255,255,.045);border:1px solid rgba(233,217,168,.22);padding:4px 18px 14px}
.ledger h2{font-family:var(--mono);font-size:.66rem;letter-spacing:.15em;text-transform:uppercase;color:#c8a86a;padding:12px 0 8px;border-bottom:1px solid rgba(255,255,255,.13)}
.ledger ol{list-style:none}
.ledger li{display:flex;gap:12px;padding:9px 0;border-bottom:1px solid rgba(255,255,255,.08);font-size:.86rem}
.ledger li:last-child{border-bottom:none}
.ledger li s{text-decoration:none;font-family:var(--mono);font-size:.68rem;color:#7f9497;padding-top:2px}
.ledger li a{border:none;color:#e6eeef}
.ledger li a:hover{color:#f4e2ad}

/* ---------- page frame ---------- */
.frame{padding:34px 0 64px}
.crumbs{font-family:var(--mono);font-size:.68rem;letter-spacing:.08em;text-transform:uppercase;color:var(--ink-3);margin-bottom:20px}
.crumbs a{color:var(--ink-3);border:none}
.crumbs a:hover{color:var(--pine)}
.crumbs s{text-decoration:none;margin:0 8px;color:var(--rule-2)}

/* three-column article frame: contents / body / glance */
.cols{display:grid;grid-template-columns:216px minmax(0,1fr) 264px;gap:40px;align-items:start}
.cols.two{grid-template-columns:216px minmax(0,1fr)}
@media(max-width:1040px){.cols,.cols.two{grid-template-columns:minmax(0,1fr)}}
.toc{position:sticky;top:82px}
.toc h2{font-family:var(--mono);font-size:.64rem;letter-spacing:.14em;text-transform:uppercase;color:var(--ink-3);padding-bottom:8px;border-bottom:2px solid var(--ink)}
.toc ol{list-style:none;counter-reset:t}
.toc li{counter-increment:t;border-bottom:1px dotted var(--rule-2)}
.toc li a{display:block;padding:8px 0 8px 26px;position:relative;font-size:.82rem;color:var(--ink-2);border:none;line-height:1.45}
.toc li a::before{content:counter(t,decimal-leading-zero);position:absolute;left:0;top:9px;font-family:var(--mono);font-size:.62rem;color:var(--rust)}
.toc li a:hover{color:var(--pine)}
@media(max-width:1040px){.toc{position:static;margin-bottom:26px}}

article h1{font-size:1.98rem;line-height:1.24;margin-bottom:12px}
.standfirst{font-size:1.06rem;color:var(--ink-2);border-left:2px solid var(--rust);padding-left:16px;margin:14px 0 22px}
article p{margin-bottom:15px}
article h2{font-size:1.24rem;margin:34px 0 12px;padding-bottom:8px;border-bottom:1px solid var(--rule);position:relative}
article h2 em{font-family:var(--mono);font-style:normal;font-size:.62rem;color:var(--rust);letter-spacing:.1em;display:block;margin-bottom:5px}
article h3{font-size:1rem;margin:20px 0 6px;color:var(--pine-2)}
article ul,article ol{margin:0 0 16px 20px}
article li{margin-bottom:7px}
.keyline{background:var(--wash);border-left:3px solid var(--pine);padding:14px 18px;margin:0 0 20px;font-size:.93rem;color:var(--ink-2)}

/* quick summary ledger */
.quick{background:var(--surface);border:1px solid var(--rule);border-top:2px solid var(--pine);padding:16px 20px 18px;margin:0 0 26px}
.quick h2{font-family:var(--mono);font-size:.64rem;letter-spacing:.14em;text-transform:uppercase;color:var(--pine);border:none;margin:0 0 10px;padding:0}
.quick ul{list-style:none;margin:0}
.quick li{position:relative;padding-left:18px;font-size:.9rem;color:var(--ink-2);margin-bottom:7px}
.quick li::before{content:"";position:absolute;left:2px;top:.62em;width:6px;height:6px;border:1px solid var(--rust);transform:rotate(45deg)}

/* data table */
.tbl{overflow-x:auto;border:1px solid var(--rule);margin:18px 0 22px;background:var(--surface)}
table.ref{width:100%;border-collapse:collapse;font-size:.85rem}
table.ref caption{caption-side:top;text-align:left;padding:10px 14px;font-family:var(--mono);font-size:.64rem;letter-spacing:.08em;text-transform:uppercase;color:var(--ink-3);border-bottom:1px solid var(--rule);background:#f8faf9}
table.ref th{text-align:left;padding:9px 14px;background:var(--ink);color:#e8eef0;font-family:var(--mono);font-size:.62rem;letter-spacing:.1em;text-transform:uppercase;font-weight:500}
table.ref td{padding:9px 14px;border-bottom:1px solid var(--rule);color:var(--ink-2);vertical-align:top}
table.ref tr:nth-child(even) td{background:#fbfcfc}
table.ref tr:last-child td{border-bottom:none}

/* pros / cons ledger */
.split{display:grid;grid-template-columns:1fr 1fr;gap:18px;margin:18px 0 22px}
@media(max-width:680px){.split{grid-template-columns:1fr}}
.split div{border:1px solid var(--rule);background:var(--surface);padding:14px 18px}
.split h3{font-family:var(--mono);font-size:.64rem;letter-spacing:.13em;text-transform:uppercase;margin:0 0 8px;color:var(--ink-3)}
.split ul{list-style:none;margin:0}
.split li{font-size:.88rem;padding:6px 0 6px 16px;position:relative;border-bottom:1px dotted var(--rule-2);color:var(--ink-2)}
.split li:last-child{border-bottom:none}
.split li::before{position:absolute;left:0;top:6px;font-size:.8rem}
.split .up li::before{content:"+";color:var(--pine);font-weight:700}
.split .down li::before{content:"\2212";color:var(--rust);font-weight:700}

/* faq */
.faq{margin:34px 0 0;border-top:2px solid var(--ink);padding-top:18px}
.faq h2{border:none;margin:0 0 12px;padding:0}
.faq details{border-bottom:1px solid var(--rule);background:var(--surface)}
.faq details:first-of-type{border-top:1px solid var(--rule)}
.faq summary{cursor:pointer;list-style:none;padding:13px 40px 13px 16px;font-weight:600;font-size:.93rem;position:relative;color:var(--ink)}
.faq summary::-webkit-details-marker{display:none}
.faq summary::after{content:"+";position:absolute;right:14px;top:11px;font-family:var(--mono);color:var(--rust);font-size:1rem}
.faq details[open] summary::after{content:"\2212"}
.faq details p{padding:0 16px 15px;margin:0;font-size:.9rem;color:var(--ink-2)}

/* glance rail */
.glance{position:sticky;top:82px;display:flex;flex-direction:column;gap:16px}
@media(max-width:1040px){.glance{position:static;order:3}}
.gcard{border:1px solid var(--rule);background:var(--surface);padding:15px 17px}
.gcard h3{font-family:var(--mono);font-size:.62rem;letter-spacing:.13em;text-transform:uppercase;color:var(--ink-3);margin:0 0 9px;border:none;padding:0}
.gcard dl{font-size:.83rem}
.gcard dt{font-family:var(--mono);font-size:.6rem;letter-spacing:.1em;text-transform:uppercase;color:var(--rust);margin-top:9px}
.gcard dd{color:var(--ink-2);margin:1px 0 0}
.gcard ul{list-style:none;margin:0}
.gcard li{font-size:.84rem;padding:6px 0;border-bottom:1px dotted var(--rule-2)}
.gcard li:last-child{border-bottom:none}
.gcard li a{border:none}
.gcard p{font-size:.83rem;color:var(--ink-3)}

/* hub ledger rows */
.rows{list-style:none;margin:22px 0 0;border-top:2px solid var(--ink)}
.rows li{display:grid;grid-template-columns:34px minmax(0,1fr) 120px;gap:14px;padding:15px 0;border-bottom:1px solid var(--rule);align-items:baseline}
@media(max-width:640px){.rows li{grid-template-columns:26px minmax(0,1fr)}.rows li s{display:none}}
.rows li s{text-decoration:none;font-family:var(--mono);font-size:.66rem;color:var(--rust)}
.rows li a{font-family:Georgia,serif;font-size:1.02rem;border:none;color:var(--ink)}
.rows li a:hover{color:var(--pine)}
.rows li p{font-size:.85rem;color:var(--ink-3);margin:3px 0 0}
.rows li em{font-family:var(--mono);font-style:normal;font-size:.64rem;color:var(--ink-3);text-align:right;letter-spacing:.06em;text-transform:uppercase}

/* hub grid on home */
.hubgrid{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:0;border-top:2px solid var(--ink);border-left:1px solid var(--rule);margin:24px 0 8px}
@media(max-width:900px){.hubgrid{grid-template-columns:repeat(2,minmax(0,1fr))}}
@media(max-width:560px){.hubgrid{grid-template-columns:1fr}}
.hubgrid a{display:block;border:none;border-right:1px solid var(--rule);border-bottom:1px solid var(--rule);padding:18px 18px 20px;background:var(--surface);min-height:132px}
.hubgrid a:hover{background:#f9fbfa}
.hubgrid b{display:block;font-family:var(--mono);font-size:.6rem;letter-spacing:.12em;text-transform:uppercase;color:var(--rust);margin-bottom:8px;font-weight:600}
.hubgrid strong{display:block;font-family:Georgia,serif;font-size:1rem;color:var(--ink);line-height:1.35}
.hubgrid span{display:block;font-size:.82rem;color:var(--ink-3);margin-top:6px}

/* notice + disclaimer */
.notice{border:1px dashed var(--rule-2);background:#fbfcfc;padding:15px 18px;font-size:.83rem;color:var(--ink-3);line-height:1.68}
.notice b{color:var(--ink-2)}
.footnote{font-size:.8rem;color:var(--ink-3);margin-top:10px}

/* inline sponsor ribbon (shimmer + sweep) */
.sponsor{display:none;position:relative;overflow:hidden;margin:26px 0;border:1px solid #0a4640;background:linear-gradient(96deg,#083f39,#11695e,#0d5a51,#8a6a2b,#083f39);background-size:320% 100%;animation:sprFlow 8s linear infinite;box-shadow:0 10px 26px -22px rgba(8,63,57,.9)}
.sponsor a{display:flex;align-items:center;gap:14px;justify-content:center;flex-wrap:wrap;border:none;padding:13px 18px;color:#fff;text-align:center}
.sponsor a b{font-weight:700;font-size:.9rem;letter-spacing:.01em}
.sponsor a i{font-family:var(--mono);font-style:normal;font-size:.62rem;letter-spacing:.12em;text-transform:uppercase;color:#f0dfae;border:1px solid rgba(240,223,174,.5);padding:2px 7px}
.sponsor::after{content:"";position:absolute;inset:0;pointer-events:none;background:linear-gradient(104deg,transparent 36%,rgba(255,255,255,.42) 48%,rgba(255,244,203,.30) 54%,transparent 63%);transform:translateX(-115%);animation:sprSweep 3.2s ease-in-out infinite}
@keyframes sprFlow{to{background-position:-320% 0}}
@keyframes sprSweep{0%{transform:translateX(-115%)}52%,100%{transform:translateX(118%)}}

.sponsor.is-on{display:block}

/* fixed dock — the only persistent ad unit */
.dock{position:fixed;left:0;right:0;bottom:0;z-index:95;display:none;overflow:hidden;border-top:1px solid #062d29;
  background:linear-gradient(99deg,#062d29,#0f6a5e,#0a4a43,#96702c,#062d29);background-size:340% 100%;animation:sprFlow 7s linear infinite}
.dock a{position:relative;display:block;border:none;padding:11px 18px;text-align:center;color:#fff}
.dock a b{font-size:.86rem;font-weight:700}
.dock a u{display:block;text-decoration:none;font-family:var(--mono);font-size:.6rem;letter-spacing:.13em;text-transform:uppercase;color:#f2e3b6;margin-top:2px;animation:sprPulse 2.6s ease-in-out infinite}
.dock::after{content:"";position:absolute;inset:0;pointer-events:none;background:linear-gradient(104deg,transparent 40%,rgba(255,255,255,.40) 50%,rgba(255,242,196,.26) 56%,transparent 66%);transform:translateX(-120%);animation:sprSweep 2.8s linear infinite}
@keyframes sprPulse{0%,100%{opacity:.65}50%{opacity:1}}
@media(prefers-reduced-motion:reduce){
  .sponsor,.dock{animation:none}
  .sponsor::after,.dock::after{animation:none;opacity:0}
  .dock a u{animation:none}
  .bar{transition:none}
}

/* footer */
.foot{background:var(--surface);border-top:3px solid var(--ink);padding:40px 0 0;font-size:.86rem}
.fgrid{display:grid;grid-template-columns:1.4fr 1fr 1fr 1fr;gap:32px;padding-bottom:30px}
@media(max-width:860px){.fgrid{grid-template-columns:1fr 1fr}}
@media(max-width:520px){.fgrid{grid-template-columns:1fr}}
.foot h4{font-family:var(--mono);font-size:.62rem;letter-spacing:.13em;text-transform:uppercase;color:var(--ink-3);margin-bottom:11px}
.foot a{display:block;color:var(--ink-2);border:none;padding:3px 0;font-size:.85rem}
.foot a:hover{color:var(--pine)}
.foot .fname{font-family:Georgia,serif;font-size:1.02rem;color:var(--ink);margin-bottom:8px}
.foot .fname small{display:block;font-family:var(--mono);font-size:.6rem;letter-spacing:.12em;text-transform:uppercase;color:var(--ink-3);margin-top:4px}
.flegal{border-top:1px solid var(--rule);padding:16px 0 58px;font-size:.78rem;color:var(--ink-3);line-height:1.7}

/* 404 */
.lost{padding:70px 0;max-width:640px}
.lost h1{font-size:2.2rem;margin-bottom:12px}
.lost p{color:var(--ink-2);margin-bottom:16px}
.lost a.back{display:inline-block;padding:9px 16px;background:var(--ink);color:#fff;border:none;font-size:.85rem}

@media(max-width:880px){
  .hero .wrap{grid-template-columns:1fr;gap:30px;padding:38px 24px 40px}
  .hero h1{font-size:1.78rem}
  article h1{font-size:1.56rem}
}
@media(max-width:720px){
  /* phones: the dark strip is the first thing to go, and the sticky bar tucks
     away as soon as the reader starts moving down the page */
  .utility{display:none}
  .bar{transition:transform .26s ease}
  .bar.tuck{transform:translateY(-102%)}
  .menu{display:none;position:absolute;left:0;right:0;top:100%;background:#fff;border-bottom:1px solid var(--rule);flex-direction:column;gap:0;padding:8px 24px 14px}
  .menu.open{display:flex}
  .menu a{padding:9px 0;width:100%;border-bottom:1px solid var(--rule)}
  .hamb{display:block}
  .utility .wrap span:nth-child(2){display:none}
}

/* ---- in-section index + related list headings ---- */
.hubindex,.related{margin:34px 0 0;padding-top:18px;border-top:2px solid var(--ink)}
.hubindex h2,.related h2{border:none;margin:0 0 4px;padding:0}
.related .rows li em{color:var(--ink-3)}
.hubindex .rows li em{white-space:nowrap}
.related .rows li p,.hubindex .rows li p{max-width:52em}